CRYSTAL BYERS,JEREMY LEE BARYZA,JUNPING ZHAO,THOMAS ZABAWA,CAMERON CHUCK LEE,TANZINA MUNN - FAZAL,GABRIEL GRANT GAMBER,ROHAN ERIC JOHN BECKWITH,KEITH A. BOWMAN,SHUANGXI WANG,LAURA WEST,CHANDRA VARGEES
申请号：
ARP140100778
公开号：
AR095077A1
申请日:
2014.03.10
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
The compounds of the formula (1) and to pharmaceutically acceptable salts thereof are useful in the cationic Lipid Administration of biologically active agents to cells and tissues.Claim 1: a compound according to formula (1), where l is alquileno c u2081 u208b u2086, alquenileno c u2082 u208b u2086, alquinileno c u2082 u208b u2086, - (ch u2082 u02b3 cicloalquileno c u2083 u208b u2087 - (-) - (- ch u2082) u209b, ch u2082) u209b - cicloalquenileno c u2083 u208b u2087 ( u209b ch u2082) - - - - cicloalquinileno c u2083 u208b u2087 u209b (ch u2082) - (ch u2082 u209b - * -), Alquileno c u2081 u208b u2084 L u00b2 * - - - - - alquileno c u2081 u208b u2084 L u00b2 alquileno c u2081 u208b u2084 - a remnant of formula (2) or a formula (3),Where * denotes the fraction of the Group Union nr u00b9r u00b2； L u00b2, set in any direction, is - O -, - S -, - C (o) -, - C (o) o -, - O -, OC (OR) - with - S (o) u2082nh - nhconh - or - - S nhcsnh； each is independently 0,1 or 2 t； each is independently 0, 1, 2, 3, or 4； or is 0, 1, 2, 3, 4, 5, or 6 r u00b9 and； R u00b2 are each independently c u2081 u208b u2086 optionally substituted alkyl,Alquenilo c u2082 u208b u2086 optionally substituted cycloalkyl, optionally substituted alquinilo c u2082 u208b u2086, c u2083 u208b u2087 - (ch u2082) u209b - optionally replaced, cicloalquenilo c u2083 u208b u2087 - (ch u2082) u209b - optionally replaced, cicloalquinilo c u2083 u208b u2087 - (ch u2082) u209b - optionally substituted phenyl, or (ch u2082 u209b) - optionally substituted； wherein Said c u2081 u208b u2086 alquenilo c u2082 u208b u2086 alkyl, cycloalkyl, alquinilo c u2082 u208b u2086, c u2083 u208b u2087, cicloalquenilo c u2083 u208b u2087,Cicloalquinilo c u2083 u208b u2087, and phenyl are optionally substituted by one or two substituents each independently selected from the group consisting of: Oh, c u2081 u208b u2083 alkoxyl, alkyl COOH and - Coo c u2081 u208b u2084, or r u00b9 and R u00b2 together forming a Heterocyclic Rin
