SONDE DE TOMOGRAPHIE PAR ÉMISSION DE POSITRONS (PET), O6-BENZYLGUANINE, MARQUÉE AU 11C, APTE À VISUALISER L'ACTIVITÉ O6-MÉTHYL GUANINE MÉTHYL-TRANSFÉRASE, ET PROCÉDÉS DE PRODUCTION ASSOCIÉS
An object of the invention is to provide a 11 C-labeled O 6 -benzylguanine capable of obtaining a PET image and a process for producing the same. The 11 C-labeled O 6 -benzylguanine of the invention is represented by the following chemical formula (a). The 11 C-labeled O 6 -benzylguanine is produced by: a coupling step of cross-coupling a methyl iodide labeled with 11 C and the following organotin compound (b) (R 1 represents an alkyl group, and R 2 and R 3 represent a leaving group which can be eliminated with a base.) in the presence of a palladium complex, a phosphine ligand, and cuprous halide in an aprotic lactam； and a desorption step of desorbing the leaving groups R 2 and R 3 of the coupling product obtained by the coupling step with a base.
