Marcus F. Boehm,Esther Martinborough,Manisha Moorjani,Liming Huang,Junko Tamiya,Mark T. Griffith,Thomas Fowler,Andrew Novak,Michael Knaggs,Premji Meghani
申请号：
US13936815
公开号：
US08816121B2
申请日:
2013.07.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analysis of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.
