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NOVEL SALTS OF (2R)-4-OXO-4-OXO4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]-TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHYENYL)BUTAN-2-AMINE
专利权人:
发明人:
PANDEY BIPIN,DAVE MAYANK GHANSHYAMBHAT,KOTHARI HIMANSHU M,SHUKLA BHAVIN SHRIPRASAD
申请号:
IN591/MUM/2011
公开号:
IN2011MU00591A
申请日:
2011.03.03
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
"The oresent invention discloses new salts of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro[l,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine i.e. gentisate, adipate and trifluoro acetic acid salts. The invention also describes the new crystalline and amorphous forms of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]-triazoto[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine gentisate. The present invention also discloses novel crystalline salt form of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride and novel crystalline and amorphous salt forms of besylate and process for their preparation and isolation.
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