The present invention relates to the use of VEGF antagonists and alpha5beta1antagonists for treating cancer and inhibiting angiogenesis and/or vascularpermeability, including inhibiting abnormal angiogenesis in diseases. Thepresent invention also relates to use of a VEGFR agonists and alpha5beta1 agoniststo promote angiogenesis and vascular permeability. The present invention alsorelates to new anti-alpha5beta1 antibodies, compositions and kits comprisingthem and methods of making and using them.