Sulphated hyaluronic acid grade 2 is disclosed with 2 to 60% mole, it is preferred that 15 to 35%), even more preferably between 20 and 25%, carboxy-functionalized directly or by a spacer there is amino to form amido bond with dopamine by what amido bond was conjugated, and the dopamine of amido bond and amino is formed with the carboxyl and carboxyl of hyaluronic acid.