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Reduction of toxicity of multi-targeting antifolates
专利权人:
发明人:
Bengt Gustavsson,Göran Carlsson
申请号:
US14811905
公开号:
US09585888B2
申请日:
2015.07.29
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The use of tetrahydrofolate, methylene-tetrahydrofolate and/or methyl-tetrahydrofolate, and at least one multi-targeting antifolate, for the manufacture of a pharmaceutical composition for the treatment of cancer is disclosed. By combining the multi-targeting antifolate with tetrahydrofolate, methylene-tetrahydrofolate and/or methyl-tetrahydrofolate, it is possible to remarkably reduce toxic side-effects without diminishing the anti-tumor action of the drugs. A pharmaceutical composition, a kit comprising the pharmaceutical composition as well as a method for the treatment of cancer are also disclosed.
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