Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.特定化合物有效於預防與治療疾病,如HGF仲介之疾病。本發明包括新穎之化合物,同系物,前藥及其藥學上可接受鹽,醫藥組成物與預防與治療有關癌症等等疾病與其他病症或病況的方法。本發明亦有關於製造這些化合物的方法以及用於這些方法的中間物。