Provided are an aptamer bound to chymase to inhibit activity of chymase； an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T； a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like)； a pharmaceutical or a reagent containing the aptamer or complex； a detection and a purification methods of chymase using the aptamer or complex and the like.係提供結合至凝乳酶以抑制凝乳酶活性之適體；包含X1GAUAGAN1N2UAAX2所示之核苷酸序列之適體，其中不論相同或不同，X1與X2各為A或G，且不論相同或不同，N1與N2各為A、G、C、U或T；包括適體以及官能物質(例如親和性物質、標識性物質、酵素、藥物遞送介質或藥物等)之複合物；包括適體或複合物之醫藥品或試劑；使用適體或複合物之偵測或純化凝乳酶之方法等。
