PURPOSE: A pharmaceutical composition for prevention or treatment of inflammation diseases including archidendron clypearia methanol extract is provided to be able to be used in prevention or treatment of inflammation diseases by suppressing the activation of Src, Syk and IRAK-1, which are tyrosine kinase.CONSTITUTION: A pharmaceutical composition for prevention or treatment of inflammation diseases includes archidendron clypearia methanol extract as an active ingredient. The inflammation diseases include chronic inflammation progressed to a disease condition, an inflammation by generally harmless substances such as pollen, and an inflammation by the autoimmune response such as asthma or rheumatoid arthritis. The inflammation diseases are selected from the group consisting of sepsis, dermatitis, allergy, atopic dermatitis, asthma, conjunctivitis, periodontitis, rhinitis, tympanitis, laryngopharyngitis, tonsillitis, pneumonia, gastric ulcer, gastritis, Crohns disease, colitis, hemorrhoid, gout, ankylosing spondylitis, rheumatic fever, lupus, fibromyalgia, psoriatic arthritis, osteoarthritis, rheumatoid arthritis, periarthritis of shoulder, tendinitis, tenosynovitis, peritendinitis, myositis, hepatitis, cystitis, nephritis, Sjogren’s syndrome, multiple sclerosis, acute inflammation diseases and chronic inflammatory diseases. The methanol extract is extracted by applying the pressure of 1,000-2,000 psi at 40-70deg.C and cultivating for 1-5 days after archidendron clypearia is dipped in methanol.COPYRIGHT KIPO 2013본 발명은 아키덴드론 클리페어리아 메탄올 추출물을 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 보다 구체적으로는 티로신 인산화효소(tyrosine kinase)인 Src, Syk 및 IRAK-1의 활성을 억제하여 염증성 질환을 예방 또는 치료하는데 사용할 수 있는 약학적 조성물에 관한 것이다. 본 발명의 아키덴드론 클리페어리아 메탄올 추출물은 독성이 적으며, 효과적으로 염증 및 자가면역 활성에 관여하는 사이토카인과 그에 따른 신호전달 단백질의 발현을 효과적으로 억제하기 때문에, 다양한 염증성 질환에 폭넓게 이용될 수 있을 것으로 기대된다.
