CHEN YI,KABARIA NIMESH,WANG KAI-ROY,XU HUI,LEAMY PATRICK
申请号：
IN201617010547
公开号：
IN201617010547A
申请日:
2016.03.28
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen containing tissue matrix with a proteolytic enzyme has altered the at least one collagen containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.
