Soo Sung Ko,Douglas G Batt,Myra Beaudoin Bertrand,George Delucca,Charles M. Langevine,Qingjie Liu,Anurag S. Srivastava,Scott Hunter Watterson
申请号：
US14392355
公开号：
US09714234B2
申请日:
2014.06.25
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are compounds of Formula (I) and salts thereof, wherein: Formula (II) Q is: R1 is —C(CH3)2OH, —NHC(=0)C(CH3)3, —N(CH3)2, or —CH2Rd R2 is CI or —CH3 R3 is H, F, or —CH3 Ra is H or —CH3 Rb is H, F, CI, or —OCH3 Rc is H or F and Rd is —OH, —OCH3, —NHC(=0)CH3, or fORMULA (III), Also disclosed are methods of using such compounds as inhibitors of Brutons tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
