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DOMAINES DE SIGNALISATION DE REGROUPEMENT ET DE CO-STIMULATION DANS UNE CONCEPTION DE CAR FLEXIBLE
专利权人:
Celyad S.A.
发明人:
申请号:
EP18832997.3
公开号:
EP3724339A2
申请日:
2018.12.14
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The present application relates to the field of immunotherapy, more particularly to the field of chimeric antigen receptors (CARs). Currently, second and third generation CAR designs are quite rigid in that they combine fixed costimulatory domains in cis on the same intracellular protein domain. Trans signaling is not equivalent as costimulatory receptors have different expression levels or stoichiometry. Here, a 'mix and match' approach is proposed where different signaling and costimulatory domains are present on separate chains within the same CAR complex, allowing increased flexibility and control of the nature and strength of the CAR-generated signal. Also proposed are polynucleotides, vectors encoding the transmembrane polypeptide chains and cells expressing such CARs. These cells are particularly suitable for use in immunotherapy, and strategies to treat diseases such as cancer using these cells are also provided.
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