A needle puncture device comprises: a needle base (10)； a needle (20)； a first structural member (30) disposed outside of the needle base (10), slidably engaged with the needle base (10) in an extending direction of the needle (20), and provided with a first restriction mechanism configured to restrict the first structural member (30) from separating from the needle base (10) along the extending direction of the needle (20)； and a second structural member (40) disposed outside of the first structural member (30), slidably engaged with the first structural member (30) along the extending direction of the needle (20), and provided with a second restriction mechanism configured to restrict the second structural member (40) from separating from the first structural member (30) along the extending direction of the needle (20). The first structural member (30) and the second structural member (40) are configured to receive the needle (20) inside the second structural member (40) by sliding along the extending direction of the needle (20). The present invention has the advantages of both operational convenience for an operator and skin comfort for a patient, and the structural members (30, 40) above the needle base (10) can quickly cover the needle (20) after use. In addition, connections between the structural members (30, 40) and the needle base (10) are secure, such that the structural members (30, 40) do not fall off, thereby effectively improving product safety.
