Disclosed are compositions and methods for wound care, especially fortreatment ofchronic wounds. Compositions and methods are described for inhibitingreconstructions ofbiofilm in a chronic wound or preventing expansion of a biofilm in a chronicor acute wound.In particular, compositions and medicaments of the present invention comprisemilk-derivedprotein product, bovine milk-derived protein product processed to provide anenrichedconcentration of lactoferrin, and/or isolated lactoferrin, in combination withxylitol.