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NANOPARTICLES CARRYING A CHEMOTHERAPEUTIC ANTI-CANCER MEDICINE
专利权人:
БИОАЛЬЯНС ФАРМА (FR)
发明人:
ПИЗАНИ Эмилия (FR),ЛЕБЕЛЬ-БИНЕ Софи (FR),ПОЛЯР Валери (FR)
申请号:
RU2013128934/15
公开号:
RU2013128934A
申请日:
2012.03.30
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Nanoparticles containing at least one chemotherapeutic antitumor agent, at least one poly (alkyl cyanoacrylate) and at least one cyclodextrin for use in the treatment of cancer, where the nanoparticles are administered by intravenous or intraarterial infusion for at least 2 hours . Nanoparticles according to claim 1, where the nanoparticles are administered by intravenous or intraarterial infusion for 2 to 24 hours. The nanoparticles according to claim 1 or 2, where the nanoparticles are administered by intravenous or intra-arterial infusion for 4 to 12 hours. The nanoparticles of claim 1, wherein the nanoparticles are administered by intravenous or intra-arterial infusion for about 6 hours. The nanoparticles of claim 1, wherein said at least one poly (alkyl cyanoacrylate) is polyisohexyl cyanoacrylate. The nanoparticles according to claim 1, where the nanoparticles contain the specified at least one chemotherapeutic agent in a concentration of from 0.01 to 200 mg / g of nanoparticles, from 0.1 to 70 wt.% The specified at least one cyclodextrin and from 1 to 25 mass % of said at least one poly (alkyl cyanoacrylate) .7. The nanoparticles according to claim 1, wherein said at least one chemotherapeutic antitumor agent is selected from the group consisting of anthracyclines, topoisomerase I and / or II inhibitors, plant alkaloids toxins that block the mitotic spindle, alkylating agents, antimetabolites, ellipticin and harmine and any their combinations. 8. The nanoparticles of claim 7, wherein said at least one chemotherapeutic antitumor agent is anthracycline, preferably selected from the group consisting of doxorubicin, daunorub1. Наночастицы, содержащие по меньшей мере один химиотерапевтический противоопухолевый агент, по меньшей мере один поли(алкилцианоакрилат) и по меньшей мере один циклодекстрин для применения при лечении рака, где наночастицы вводят путем внутривенной или внутриартериальной инфузии в течение по меньшей мере 2 ч.2. Наночастицы по п.1, где нан
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