MCMULLEN, TODD,LOPEZ-CAMPISTROUS, ANA,WILLIAMS, DAVID
申请号：
CA2946112
公开号：
CA2946112A1
申请日:
2015.04.17
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention includes method, pharmaceutical compositions and uses thereof for treating patients with Papillary Thyroid Carcinoma (PTC) using a Platelet Derived Growth Factor Receptor Alpha (PDGFRA) inhibitor. The PDGFRA inhibitor is preferably an antibody specific to PDGFRA and causes an increase in the sensitivity level of PTC cells to radioiodine treatment. Moreover, the antibody can be used in combination with other PDGFRA inhibitors such as tyrosine kinase inhibitors and RNA interference molecules.
