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Method to determine the ability of human EZH2 inhibitors under treatment
专利权人:
Inc.;Epizyme
发明人:
COPELAND, Robert Allen,RICHON, Victoria Marie,SCOTT, Margaret Davis,SNEERINGER, Christopher John,KUNTZ, Kevin Wayne,KNUTSON, Sarah Kathleen,POLLOCK, Roy Macfarlane
申请号:
ES11824247
公开号:
ES2570380T3
申请日:
2011.09.12
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A method of determining whether a subject who has or is suspected of having selected lymphoma and melanoma cancer is a candidate for treatment with an EZH2 inhibitor, which comprises; detecting a Y641 mutant of an EZH2 polypeptide, if present, in a sample obtained from the subject; wherein the presence of the Y641 mutant indicates that the subject is a candidate for treatment with an EZH2 inhibitor.Un método para determinar si un sujeto que tiene o se sospecha que tiene cáncer seleccionado de linfoma y melanoma es un candidato para tratamiento con un inhibidor de EZH2, que comprende; detectar un mutante Y641 de un polipéptido EZH2, si está presente, en una muestra obtenida del sujeto; en donde la presencia del mutante Y641 indica que el sujeto es un candidato para tratamiento con un inhibidor de EZH2.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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