InGeneron, Inc.;Alliance of Cardiovascular Researchers
发明人:
Eckhard Alt,Tahereh Karimi
申请号：
US14980274
公开号：
US09913865B2
申请日:
2015.12.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>；TBX5>；HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
