The present invention relates to new combination therapies of HBV-infected individuals using a Parapoxvirus ovis (PPVO) and at least one further antiviral drug, e.g., nucleoside inhibitors, such as Entecavir. The methods and combination products according to the present invention are safe and suitable for the induction of a functional cure in chronically HBV-infected patients.本發明係關於使用羊副痘疹病毒(Parapoxvirus ovis；PPVO)及至少一種額外抗病毒藥，例如核苷抑制劑，諸如恩替卡韋(Entecavir)之經HBV感染之個體的新穎組合療法。根據本發明之方法及組合產品為安全的且適於在慢性經HBV感染之患者中誘導功能性治癒。
