A safe self-destructive syringe, characterized in that: the syringe comprises a barrel (1), a plunger rod (2), an internal needle seat body (21) disposed in the barrel neck (4) of the barrel (1), the internal needle seat body (21) being an integrally single-body structure, and the internal needle seat body (21) being disposed with an elastic sealing position-limiting base (7). The surface of the elastic sealing position-limiting base (7) is provided with an annular buffer gap (9). An annular sealing position-limiting engagement portion (10) is formed at the outer wall of the elastic sealing position-limiting base (7) outside of the annular buffer gap (9). The end of the plunger rod (2) is provided with a metal hook (11). The syringe uses a single body internal needle seat structure, such that the internally set annular buffer gap (9) enables the internal needle seat body (21) to have a certain stretching and deformation property, thereby achieving stable, complementary lock with the barrel neck (4). At the same time, a buffer zone reduces the pullback force needed to withdraw the internal needle seat, so that the locking force and the pullback force are balanced. The syringe achieves the effects of stable lock and seal without being influenced by the external environment. The syringe final product is relatively pragmatic, easy to operate, requires relatively weak pullback force, and has a stable overall operation state.Seringue de sécurité à auto-destruction caractérisée en ce quelle comprend un corps de seringue (1), une tige de piston (2), un corps siège daiguille interne (21) disposé dans le col du corps de seringue (4), le corps siège daiguille interne (21) constituant une structure unitaire monobloc et le corps siège daiguille interne (21) étant disposé avec une base de limitation de position détanchéité élastique (7). La surface de la base de limitation de position détanchéité élastique (7) présente un espace tampon annulaire (9). Une partie de mise en prise d
