Willem DOKTER,Peter Johannes GOEDINGS,Gijsbertus Franciscus Maria VERHEIJDEN,Patrick Henry BEUSKER
申请号：
US16456177
公开号：
US20190314513A1
申请日:
2019.06.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours and haematological malignancies expressing HER2, in particular breast cancer, gastric cancer, bladder cancer, ovarian cancer, lung cancer, prostate cancer, pancreatic cancer, colorectal cancer, head and neck squamous cell cancer or osteosarcoma, and acute lymphoblastic leukaemia. In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of human solid tumours with HER2 IHC 2+ or 1+ and HER2 FISH negative tissue status. Advantageously, the present invention relates to duocarmycin-containing ADCs for use in the treatment of triple negative breast cancer (TNBC).
