Compositions and methods are provided for cancer treatments. The methodology entails, for instance, administering to a cancer patient a first composition comprising a plurality of bacterially derived intact minicells or intact killed bacterial cells, each of which encompasses an anti-neoplastic agent and carries a bispecific ligand on the surface, the ligand having specificity for a mammalian cell component, and a second composition comprising interferon-gamma (IFN-gamma) or an agent that increases the expression of IFN-gamma in the subject. The compositions include the first composition and the second composition as described, optionally with additional anti-neoplastic agents.組成物和方法被提供用於癌症治療。該方法學必需，例如，投藥給一癌症病患一包含有複數個細菌衍生的完整的微型細胞或完整的被殺死的細菌細胞(它們的各個包含一抗-腫瘤試劑並且攜帶一雙特異性配位體在表面上，該配位體具有對一哺乳動物細胞組分的特異性)的第一組成物，以及一包含有干擾素-γ(IFN-γ)或一增加在該個體中IFN-γ的表現的試劑的第二組成物。該等組成物包括如所描述的該第一組成物和該第二組成物，選擇性地與額外的抗-腫瘤試劑。
