The Invention provides combinations comprising a MEK Inhibitor such as GDC - 0.973, GDC - 0623, GSK - 112 0212 (trametinib bags-6244 (AZD), selumetinib), etc or one of its pharmaceutically acceptable Salts and an ERK inhibitor (such as GDC - 0.994, [(S) - 1 - (1 - (4 - chlorine - 3-fluorophenyl) - (2-hydroxyethyl) - 4 - (2 - ((1 - methyl - 5 - 1H pyrazole - il) amino) pyrimidin-4-yl) - 2 (1H) - pyridin ona].The combinations are particularly useful for treating Disorders such as cancer hiperproliferativos,La invencion proporciona combinaciones que comprenden un inhibidor de MEK tal como GDC-0973, GDC-0623, GSK-112 0212 (trametinib), AZD-6244 (selumetinib), etc o una de sus sales farmaceuticamente aceptables y un inhibidor de ERK (tal como GDC-0994, [(S)-1-(1-(4-cloro-3-fluorofenil)-2-hidroxietil)-4-(2-((1-metil-1H-pirazol-5-il)amino)pirimidin-4-il)piridin-2(1H)-ona]. Las combinaciones son particularmente utiles para tratar trastornos hiperproliferativos, tal como el cancer
