Federalnoe gosudarstvennoe byudzhetnoe obrazovatelnoe uchrezhdenie vysshego obrazovaniya "Moskovskij gosudarstvennyj universitet imeni M.V. Lomonosova" (MGU)
发明人:
Timoshenko Viktor Yurevich (RU),Тимошенко Виктор Юрьевич (RU),Konoplyannikov Mikhail Anatolevich (RU),Коноплянников Михаил Анатольевич (RU),Le-Dejgen Irina Mikhajlovna (RU),Ле-Дейген Ирина Михайловна
申请号：
RU2018147070
公开号：
RU0002722745C1
申请日:
2018.12.27
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: chemistry； medicine.SUBSTANCE: invention relates to a method of producing nanocontainers for chemotherapeutic anticancer drugs, comprising obtaining nanoparticles of mesoporous silicon by electrochemical etching of crystalline silicon plates with further mechanical grinding of the obtained porous layers, wherein plates of crystalline silicon of hole-type conductivity are used with specific resistance from 1 to 50 mOhm⋅cm, electrochemical etching of plates is performed with formation of mesoporous silicon film on its surface with thickness of 10 to 100 mcm and porosity from 50 to 80 %, for which electrochemical etching of plate is carried out in a solution containing an aqueous solution of hydrofluoric acid with volume concentration of 40–50 % and ethyl alcohol in ratio from 1:1 to 1:5 by volume, during period of time from 10 to 60 minutes with current density from 20 to 60 mA/cm2, after which obtained mesoporous silicon films are separated from plate, washed in distilled water, dried in air at room temperature, then poured with water in ratio from 1:2 to 1:3 by weight and subjected to mechanical grinding in a ball planetary mill using balls with diameter from 1 to 5 mm of solid materials, including zirconium oxide, stainless steel, tungsten carbide and similar grinding jars for 15 to 30 minutes at rotation speeds of 900 to 1100 rpm to obtain a concentrated aqueous suspension of mesoporous silicon nanoparticles with cross dimensions of 50 to 100 nm and pore size of 2 to 10 nm. Invention also relates to a method of producing nanocontainers with a chemotherapeutic anticancer preparation for combined cancer therapy.EFFECT: technical result is the disclosed method of producing nanoparticles of mesoporous silicon with given dimensions, morphology and chemical composition of the coating of the inner surface of pores, allowing complete loading thereof with anti-tumour preparations with sustained release in an aqueous medium.5 cl, 5 dwg, 2 tblИзобретение относится к с
