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Small molecule tyrosine kinase inhibitors of the spleen (SYK)
- 专利权人:
- Rigel Pharmaceuticals; Inc.
- 发明人:
- ZHANG, Jing,SINGH, Rajinder,GOFF, Dane,KINOSHITA, Taisei
- 申请号：
- ES10790003
- 公开号：
- ES2632220T3
- 申请日:
- 2010.06.14
- 申请国别(地区):
- ES
- 年份:
- 2017
- 代理人:
- 摘要：
- A compound having the formula Iz: ** Formula ** wherein R 1 is selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkylene, heterocyclyl, substituted heterocyclyl, aralkyl, heteroaralkyl, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, acyl, acylamino and acyloxy； R2a and R2b are independently selected from hydrogen, alkyl, substituted alkyl, acyl, acylamino, acyloxy, -SO-alkyl, -SO-aryl, -SO-heteroaryl, -SO2-alkyl, -SO2-aryl, -SO2-heteroary! , aryl, substituted aryl, heteroaryl, heterocyclyl, aralkyl and heteroaralkyl； and where R2a or R2b is present； R3 is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, halo, nitro, cyano, hydroxy, alkoxy, carboxyl, acyl, acylamino, aminoacyl, acyloxy, oxiacyl, amino, substituted amino, aryl, substituted aryl, heteroaryl and substituted heteroaryl； R5 is selected from hydrogen, alkyl and substituted alkyl； and R6 is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, acyl, acylamino, acyloxy, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkylene, aralkyl, heteroaralkyl, aryl, substituted aryl, heteroaryl, heteroaryl, heteroaryl substituted, heterocyclyl and substituted heterocyclyl； or one of its salts or stereoisomers.Un compuesto que tiene la fórmula Iz:**Fórmula** en donde R1 se selecciona entre arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, cicloalquilo, cicloalquilo sustituido, cicloalquenilo, cicloalquileno sustituido, heterociclilo, heterociclilo sustituido, aralquilo, heteroaralquilo, hidrógeno, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, acilo, acilamino y aciloxi； R2a y R2b se seleccionan independientemente entre hidrógeno, alquilo, alquilo sustituido, acilo, acilamino, aciloxi, - SO-alquilo, -SO-arilo, -SO-het
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
