A method of and composition for treating a patient having Mycobacterium avium complex (MAC), and in embodiments including Mycobacterium avium subspecies paratuberculosis (MAP) and/or Mycobacterium avium subspecies hominissuis (MAH), causing one or more diseases, one embodiment of the method including administering to the patient an effective amount of one or more probiotics and administering to the patient an effective amount of ultraviolet blood irradiation (UVBI) treatment, and an embodiment of the composition including an effective amount of one or more probiotics and an effective amount of UVBI treated blood of the patient.