PALERMO MARK G,CHO YOUNG SHIN,LEVELL JULIAN ROY,TOURE BAKARY-BARRY,YANG FAN,CAFERRO THOMAS,LEI HUANGSHU,LENOIR FRANCOIS,LIU GANG,SHULTZ MICHAEL DAVID,SMITH TROY,COSTALES ABRAN Q,PFISTER KEITH BRUCE,SE
申请号：
TN2014000128
公开号：
TN2014000128A1
申请日:
2014.03.26
申请国别(地区):
TN
年份:
2015
代理人:
摘要：
The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formual (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
