您的位置: 首页 > 农业专利 > 详情页

CERTAIN PROTEIN KINASE INHIBITORS
专利权人:
SHANGHAI FOCHON PHARMACEUTICAL CO.; LTD
发明人:
WANG Weibo (US),ВАН Вэйбо (US),ZHAO Xingdong (US),ЧЖАО Синдун (US),LI Tongshuang (CA),ЛИ Туншуан (CA),TIAN Qiang (CN),ТЯНЬ Цян (CN),ZHANG Huajie (CN),ЧЖАН Хуацзе (CN),TAN Haohan (CN),ТАНЬ Хаохань (CN)
申请号:
RU2016151315
公开号:
RU0002671494C2
申请日:
2015.05.27
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I) and/or a pharmaceutically acceptable salt thereof. In formula (I), X is C; Y is O or S; 6 to 5-member condensed ring system A-B is selected from:and ,Q is selected from heteroaryl; R1 is selected from: hydrogen, C1-6 alkyl, heterocyclyl, heterocyclyl-C1-4 alkyl, wherein heterocyclyl is unsubstituted or is substituted with at least one substituent, wherein one, two, three or four substituents are independently selected from R6a; R2 selected from: C3-10 cycloalkyl, wherein the cycloalkyl is unsubstituted or is substituted with at least one substituent independently selected from R6a; R3 and R4 are independently selected from: hydrogen, C1-10 alkyl and C3-10 cycloalkyl; or R3 and R4 together with the nitrogen atoms to which they are attached form a 4 to 6 membered ring containing 0 or 1 heteroatom independently selected from oxygen and nitrogen and optionally substituted with 1 R6a; each R5 independently selected from: C1-10 alkyl, -C(O)R7; each R6a independently selected from: -C1-10 alkyl, -OR8, -NR7R8, -(CR9R10)tOR8, -(CR9R10)tS(O)rR8, -C(O)R7 and -C(O)NR7R8; each R7 and each R8 independently selected from: hydrogen and C1-10 alkyl, wherein alkyl is unsubstituted or substituted with one substituent R6a; or R7 and R8 together with the atom(s) to which they are attached form a heterocyclic ring comprising 6 members, containing 0 or 1 additional heteroatom, independently selected from oxygen and nitrogen, and optionally substituted with 1 R6a; each R9 and each R10 are independently selected from: hydrogen; m is independently selected from 0 and 1; each r is 2; each t is independently selected from 1, 2 and 3; wherein heteroaryl is 6-membered aromatic monocyclic rings containing from 1 to 2 heteroatoms selected from N, the remaining ring atoms being carbon atoms; 9-10 membered bicyclic rings containing from 2 to 3 heteroatoms selected from N, the remaining ring atoms being carbon atoms, and where
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充