Pharmaceutical compositions and Methods of use of Derivatives of 4 - pregenen - 11B - 17 - 21 - triol) - dione

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专利权人:

ALLERGAN; INC.

发明人:

申请号：

ARP120104261

公开号：

AR088846A1

申请日:

2012.11.12

申请国别(地区):

AR

年份:

2014

代理人:

摘要：

Pharmaceutical compositions comprising Derivatives of 4 - pregenen - 11B - 17 - 21 - triol - 3,20 Dione, and their use as Pharmaceuticals as modulators of the glucocorticoid receptor (GR) and / or the mineralocorticoid receptor (MR).Use of these compounds and their pharmaceutical compositions for the treatment of ocular Disorders associated with glucocorticoid receptor (GR) and / or the mineralocorticoid receptor (MR).Claim 1: a method for treating an Eye condition associated with the Modulation of the glucocorticoid receptor and / or mineralcorticoide that includes administering to a patient in need, a Pharmaceutical composition containing a therapeutically effective amount of at least S a compound selected from: (8S, 9S, 10R, 11S 14S, 13S, 17R) - 17 - glicoloil - 11 - hydroxy - 1013 - dimethyl - 3 - oxo - tetradecahidro 2,3,6,7,8,9,10,11,12,13,14,15,16,17 cyclopenta [] - 1H - il - 17 fenantren phenylacetate； (8S, 9S, 10R, 11S 14S, 13S, 17R) - 17 - glicoloil - 11 Hydroxy 10,13 - dimethyl - 3 - oxo - tetradecahidro cyclopenta - 1H - 2,3,6,7,8,9,10,11,12,13,14,15,16,17 [A] fenantren - il - 17 butyrate； (8S, 9S, 10R, 11S, 13S, 1 4S, 17R) - 17 - glicoloil - 11 Hydroxy 10,13 - dimethyl - 3 - oxo - 2,3,6,7,8,9,10,11,12,13,14,15,16,17 - tetradecahidro cyclopenta [] - 1H - fenantren - il - 17 propionate； (8S, 9S, 10R, 11S 14S, 13S, 17R) - 17 - glicoloil - 11 Hydroxy 10,13 - dimethyl - 3 - oxo - tetradecahidro 2,3,6,7,8,9,10,11,12,13,14,15,16,17 cyclopenta [] - 1H - fenantren IL - 17 - octanoate； (8S, 9S, 10R, 11S 14S, 13S, 17R) - 17 - glicoloil - 11 - hydroxy - dimethyl - 3 - oxo 10,13 - 2,3,6,7,8,9,10,11,12,13,14,15,16,17 - tetradecahidro cyclopenta [] - 1H - 17 - fenantren hexanoate (8R, IL；9r, 10s, 11R, 13R 14R, 17S), - 17 - glicoloil - 11 Hydroxy 10,13 - dimethyl - 3 - oxo - tetradecahidro 2,3,6,7,8,9,10,11,12,13,14,15,16,17 cyclopenta [] - 1H - il - 17 fenantren Benzoate； (8S, 9S, 10R, 11S 14S, 13S, 17R) - 17 - glicoloil - 11 Hydroxy 10,13 - dimethyl - 3 - oxo - 1H

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