This invention provides for unique immune modulation applications in transplantation processes, as well as in disease intervention and prevention directed to graft-versus-host rejection as well eliminating undesirable immunological effects resulting from immunization and vaccination. Also provided are treatments for other diseases, including Crohn's disease, primary schlerosing cholangitis, primary biliary cirrhosis, atheroschlerosis, etc. This invention also provides unique compositions for carrying out such processes.