The invention relates to alkaloid reaction products obtainable in a processwherein alkaloids are reacted with an alkylating agent, preferably thiotepa,whereafter unreacted alkylating agent and other water-soluble compounds areremoved from the reaction mixture by washing with water or a suitable aqueoussolvent, whereafter the reaction mixture is subjected to a treatment withstrong acid, preferably hydrogen chloride (HCI), to precipitate a watersoluble salt of the reaction products. The precipitated reaction productscomprise at least one quaternary alkaloid derivative and are suitable as drugsfor prophylactic or therapeutic application, particularly in the treatment ofimmunological or metabolic dysfunctions, and cancer.
