To provide a BDNF-TrkB signaling system activator useful for aiding a brain-derived neurotrophic factor in neuron generation, growth, maintain, and repair, and a BDNF-TrkB signaling system activating food composition.SOLUTION: The present invention provides a BDNF-TrkB signaling system activator containing syringaresinol-di-O-β-D-glucoside or a pharmaceutically acceptable salt thereof as an active ingredient, the activator to activate a TrkB signaling system by increased BDNF production, and also provides a BDNF-TrkB signaling system activating food composition.SELECTED DRAWING: None【課題】脳由来神経栄養因子による神経細胞の発生や成長、維持、修復に有用なBDNF-TrkBシグナル伝達系活性化剤及びBDNF-TrkBシグナル伝達系活性化用食品組成物の提供。【解決手段】シリンガレジノール-di-O-β-D-グルコシド又はその薬学的に許容される塩を有効成分とする、BDNF産生の増加によりTrkBシグナル伝達系を活性化するためのBDNF-TrkBシグナル伝達系活性化剤及びBDNF-TrkBシグナル伝達系活性化用食品組成物。【選択図】なし
