University of Pittsburgh—；Of the Commonwealth System of Higher Education;The United States Government as represented by the Department of Veterans Affairs
发明人:
Beibei Chen,Rama K. Mallampalli
申请号：
US15533978
公开号：
US10487076B2
申请日:
2015.12.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof:where:X1 is a branched or unbranched C1-10 alkyl, (CH2)s—；NH—；(CH2)t, (CH2)s—；O—；(CH2)t, or (CH2)s—；C(NH2)—；(CH2)v—；NH—；(CH2)t, where s, t and v are each, independently an integer from 1 to 5；A and B are each, independently, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups；C and D are each, independently, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-6alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-C1-6 alkyl, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups；each Rg is, independently, halogen, C1-6 alkyl, C1-6 haloalkyl, hydroxyl, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6 alkylamino, or di-C1-6alkylamino； andn1 and p1 are each, independently, integers from 1 to 10.
