A probe for use in monitoring one or more parameters of a subject is provided. The probe comprises a monitoring assembly comprising at least one acoustic port for transmitting acoustic radiation into a region of interest in the subject, at least one light output port for transmitting incident light towards the region of interest, and at least one light input port for receiving light returned from the subject. The probe comprises also at least one control mechanism comprising at least one sensing assembly configured for sensing at least one of proximity, attachment and signal quality conditions, and being configured for controlling a condition of coupling between the probe assembly and the subject, enabling to control operation of the monitoring assembly.
