Feirong GONG;Ke LIU;Yuewu LANG;Huaying FAN;Fei HAN;Hui XU;Xin CHE
发明人:
Ke Liu,Feirong Gong,Hui Xu,Yuewu Lang,Huaying Fan,Fei Han,Xin Che
申请号：
US14438409
公开号：
US20150283246A1
申请日:
2013.09.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a novel amphiphilic block copolymer and the preparation method thereof, as well as a micellar drug-loaded system formed by said copolymer and an anti-tumor drug. Said amphiphilic block copolymer comprises a hydrophilic segment and a hydrophobic segment, and the end group of said hydrophobic segment is end-capped with a hydrophobic group. Methoxypolyethylene glycol (or polyethylene glycol)-polyester block copolymer which has recognized safety is used as a fundamental material of the amphiphilic block copolymer of the present invention, and the terminal hydroxyl group of the polyester segment is modified with a hydrophobic group, whereby the compatibility between the drug molecule and the hydrophobic segments of the block copolymer is improved, and the interaction therebetween is enhanced. Moreover, a larger space for accommodating the drug molecules is provided. Said micelles are more effective in restricting the drug molecules inside the micellar core and preventing the drug from dissolved out of the micelles. Therefore, a drug-loaded micelle with high stability is obtained.
