UNIVERSIDAD DE VALPARAISO;FUNDACION COPEC UNIVERSIDAD CATÓLICA
发明人:
ZUÑIGA, Elisa,MUÑOZ, Pablo,RUBILAR, Osvaldo
申请号：
CLCL2016/050030
公开号：
WO2016/191895A1
申请日:
2016.06.04
申请国别(地区):
CL
年份:
2016
代理人:
摘要：
The invention relates to self-assembled nanofibres of chitosan and bioactive compounds, which can be used as nutraceuticals or drugs. The bioactive compounds suitable for the nanofibres of the invention are molecules of a low molecular size with acid or lactone groups, aromatic rings and hydroxyls, such as small polyphenols and mixtures thereof. The nanofibres of the invention are absorbed, without degradation, at the level of the small intestine, containing and protecting the bioactive compounds until they reach the various target organs. The nanofibres also cross the blood-brain barrier, allowing the compounds to reach the brain where they act as a controlled release system. If the bioactive compounds are neuroprotectors, such as antioxidants, the nanofibres of the invention can be used to treat or prevent neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis (ALS), as well as she strokes and other diseases related to aging or associated with oxidative stress. The invention also relates to the method for obtaining the nanofibres, which comprises mixing chitosan with the bioactive compounds and allowing self-assembly. The invention further relates to the dosage form containing the nanofibres of the invention, particularly for oral administration, such as tablets, coated tablets, powders, capsules, syrups, or others.La invención protege nanofibras de quitosano y compuestos bioactivos autoensambladas, útiles como nutracéuticos o fármacos. Los compuestos bioactivos apropiados para la nanofibras de la invención corresponden a moléculas de tamaño molecular bajo con grupos ácidos o lactonas, anillos aromáticos e hidroxilos, tales como polifenoles pequeños y sus mezclas. Las nanofibras de la invención se absorben sin degradarse a nivel de intestino delgado, conteniendo y protegiendo los compuestos bioactivos hasta llegar a los distintos órganos objetivos； sorprendentemente, atraviesan también la
