ANTICORPS MODIFIÉ DANS LEQUEL UN MOTIF COMPORTANT UN RÉSIDU CYSTÉINE EST LIÉ, CONJUGUÉ ANTICORPS MODIFIÉ-MÉDICAMENT COMPORTANT L'ANTICORPS MODIFIÉ, ET SON PROCÉDÉ DE FABRICATION
PARK, SOON JAE,CHUNG, HYE-SHIN,KWON, SEONHUN,LEE, SUNBAE,YOU, SUN-AH,KIM, YONG MO
申请号：
EP13752075
公开号：
EP2818480A4
申请日:
2013.02.22
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The present invention relates to an antibody in which a motif composed of an amino acid or peptide sequence including one or more cysteine residues is bound to the terminus of a parent antibody, particularly the terminus of the heavy chain of the parent antibody. Also, the present invention relates to a modified antibody-drug conjugate (mADC) comprising a drug bound to the antibody, and a method for producing the antibody or the modified antibody-drug conjugate. The modified antibody-drug conjugate according to the invention can accurately deliver the drug to a target cell due its high specificity to antigen, and thus can increase the therapeutic effect of the drug. Also, it can increase the usability of drugs, particularly anticancer drugs, the use of which is restricted due to their toxicity, despite their high efficacy. Moreover, the invention relates to a composition for treatment of diseases, particularly cancers, which comprise the modified antibody-drug conjugate.
