An anti-aspiration device for a medical tube may comprise of at least one expandable/extendable membrane that once inserted within the cavity of an organ, will abut against interior walls of the cavity of the organ thereby creating a seal to reduce aspiration. One alternate embodiment may comprise of at least two membranes. Another alternate embodiment may comprise of a membrane configured to conform to the boundaries of the interior walls of the cavity of the organ. The device may include sensors and alert system to further enhance the attention towards needed adjustment or removal of the medical tube.