MADERNA, Andreas,DOROSKI, Matthew David,CHEN, Zecheng,RISLEY, Hud Lawrence,CASAVANT, Jeffrey Michael,O'DONNELL, Christopher John,PORTE, Alexander M.,SUBRAMANYAM, Chakrapani
申请号：
ES15708273
公开号：
ES2722103T3
申请日:
2015.01.14
申请国别(地区):
ES
年份:
2019
代理人:
摘要：
A compound of Formula (I): F1-L1-T-L2-F2 (I) or a pharmaceutically acceptable salt thereof, in which: each of F1 and F2 is independently selected from ring systems A, B, C and D: ** (See formulas) ** each R is independently selected from the group consisting of H, -C1-C20 alkyl, -C2-C6 alkenyl, - C2-C6 alkynyl, halo, hydroxy, alkoxy, - NH2, -NH (CγC8 alkyl), -N (C1-C8 alkyl) 2, -NO2, -C6-C14 aryl and - C6-C14 heteroaryl, in which two or more Rs are optionally joined to form a ring or rings , and wherein said -C6-C14 aryl and -C6-C14-heteroaryl are optionally substituted with 1 to 5 substituents independently selected from -C1-C10 alkyl, -C1-C10 alkoxy, -halo, -C1-C10 alkylthio , -trifluoromethyl, - NH2, -NH (C1-C8 alkyl), -N (C1-C8 alkyl) 2, -C1-C10-N alkyl (C1-C8 alkyl) 2, -C1-C3 alkylthio, -NO2 or -heterocyclyl C1-C10, for each ring system in which R appears； each V1 is independently a link, O, N (R) or S, for each ring system in which V1 appears； each V2 is independently O, N (R) or S, for each ring system in which V2 appears； each of W1 and W2 is independently H, or -C1-C5 alkyl, for each ring system in which W1 and W2 appear； each X is independently -OH, -O-acyl, azido, halo, cyanate, thiocyanate, isocyanate, thioisocyanate, or ** (See formula) ** for each ring system in which X appears； Each Y is independently selected from the group consisting of H, -C1-C6-RA alkyl, -C (O) Ra, -C (S) Ra, - C (O) ORa, -S (O) 2ORa, - C (O) N (Ra) 2, -C (S) N (Ra) 2, glycosyl, -NO2 and -PO (ORa) 2, for each ring system in which Y appears, in which each RA is independently selects from the group consisting of H, -C1-C20 alkyl, -C1-C8 heteroalkyl, -C6-C14 -aryl, aralkyl, -C1-C10 heterocyclyl, -C3-C8 -carbocyclyl and -C1-C20-1 alkyl (R ) 2, wherein said -C1-C20 alkyl, -C1-C8 heteroalkyl, -C6-C14 aryl, aralkyl, -C1-C10 heterocyclyl, - C3-C8 carbocyclyl and -C1-C20 N (R) 2 alkyl optionally substituted with 1 to 3 substituents independently selected from R； each Z is independently sel
