Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.本文提供哌嗪胺基甲酸酯(piperazine carbamate)及包含該等化合物之醫藥組合物。本發明化合物及組合物適用作MAGL之調節劑。此外,本發明化合物及組合物適用於治療疼痛。