The present invention provides a composition that is specific PTEN (phosphatase and tensin homolog) genetic siRNA, wherein the siRNA comprises the injected transfected cells, and this. The compositions of the present invention shows an excellent function and effect in the prevention, treatment and / or secondary treatment of chronic autoimmune diseases, such as cancer.PTEN, siRNA, apoptosis inhibition, maturation, dendritic cells, immune response enhancer, cancer본 발명은 PTEN (phosphatase and tensin homolog) 유전자 특이적 siRNA, 상기 siRNA가 형질 주입된 세포, 및 이를 포함하는 조성물을 제공한다. 본 발명의 조성물은 암과 같은 만성면역질환의 예방, 치료 및/또는 보조치료에 우수한 작용효과를 나타낸다.