FLOCKERZI, DIETER,KAUTZ, ULRICH,HATZELMANN, ARMIN,ZITT, CHRISTOF,WOHLSEN, ANDREA,MARX, DEGENHARD,KLEY, HANS-PETER,CHRISTOFFERS, JENS,ROSIAK, ANNA
申请号：
CA2579000
公开号：
CA2579000C
申请日:
2005.09.05
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
In one of its aspects, the present invention relates to a compound of formula1(see formula 1)in whichA is S, S(O) or S(O)2,R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxywhich iscompletely or predominantly substituted by fluorine,R2 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxywhich iscompletely or predominantly substituted by fluorine,or in whichR1 and R2 together are a 1-2C-alkylenedioxy group,R3 is a phenyl radical which is substituted by R4 and R5, whereinR4 is hydrogen, hydroxyl, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,R5 is CO-R6 or CO-R7, whereinR6 is hydroxyl, 1-8C-alkoxy, 3-7C-cycloalkoxy or 3-7C-cycloalkylmethoxy andR7 is N(R71)R72, wherein R71 and R72 independently of one another arehydrogen,1-7C--alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, or wherein R71 and R72,together andincluding the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidyl,1--hexahydroazepinyl or 4-morpholinyl radical,or a hydrate, solvate or salt thereof, or a hydrate or solvate of a saltthereof, or a N-oxide thereof,or a salt, hydrate or solvate of the latter. The compounds are useful, interalia, for the treatmentand/or prophylaxis of a respiratory disease or a dermatosis.
