Factor VIII safe for viruses containing low content of higher order multimers

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专利权人:

ラボラトワール・フランセ・デュ・フラクシオンマン・エ・デ・ビョテクノロジー

发明人:

シュトゥルー、アブドゥサタール,ノーグル、ミシェル,シュミットアウスレ、ローラン

申请号：

JP2006536134

公开号：

JP4872669B2

申请日:

2004.10.25

申请国别(地区):

JP

年份:

2012

代理人:

摘要：

Factor VIII composition (A) of plasma origin and free of virus is produced by filtration through a nanometer filter of nominal pore opening 15+-2 nm to 23+-2 nm and includes von Willebrand factor (vWF) with not over 15% in the form of decamers or higher multimers. Independent claims are also included for the following: (1) method for testing the viral security of a factor VIII composition of plasma origin, prepared by nanometer filtration, by determining the level of residual highly multimeric vWF； and (2) method for preparing (A) by filtration through a specified filter and determining the proportion of vWF present as decamers or higher multimers. ACTIVITY : Hemostatic. No biological data is given. MECHANISM OF ACTION : Protein replacement.

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中国工程科技知识中心

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http://www.ckcest.cn/home/