A hand-held drug delivery apparatus for use for the treatment of asthma and other pulmonary disorders such as pulmonary hypertension and hypotoxic hypoxemic conditions is disclosed. The apparatus comprises a nebuliser (1) for generating an aerosol of a medicament, a hollow tubing (2) connected to said nebuliser (1) for the passage of aerosol, an atomiser (3) connected to said hollow tubing (2) for converting said aerosol into microglobules containing said medicament, a reservoir (7) connected to said atomiser (3) for allowing said atomised microglobules containing said medicament a predetermined resident time for said microglobules to achieve a predetermined size and humidity and result in complete delivery of the medicine to peripheral lung parenchyma and avoid significant deposition in oropharynx, trachea and stomach, when inhaled by the patient, a mouth piece (4) connected between said atomiser (3) and reservoir (7) for facilitating inhalation of said microglobules containing said medicament by said patient, and a valve (6) for controlling the passage of said atomised microglobules into either the mouthpiece (4) or reservoir (7).
