The present invention provides a composition comprising a therapeutically effective amount of a polypeptide, peptide, or analog corresponding to one or more of SEQ ID NO(s) 1, 2, 3 or 4, and or more of a pharmaceutically acceptable carrier, pharmaceutically acceptable diluent, and/or pharmaceutically acceptable excipient. The polypeptide therapeutic of the present invention may be formulated for administration to a subject in need of treatment as an oral formulation, a parenteral formulation, a topical formulation, an aqueous formulation, a solid formulation, a lyophilized formulation, or a trans-dermal formulation. Also disclosed is a method for treating at least one of diabetes, and/or hyperglycemia, and/or hypercholesterolemia, and/or hypertension, and/or metabolic syndrome in a subject, comprising: administering to the subject a polypeptide of the invention or formulation of the invention.La presente invencion provee una composicion que comprende una cantidad terapeuticamente efectiva de un polipeptido, peptido o analogo que corresponde a una o mas de SEQ ID NO(s) 1, 2, 3 o 4, y/o uno o mas de un vehiculo farmaceuticamente aceptable, diluyente farmaceuticamente aceptable y/o excipiente farmaceuticamente aceptable； el polipéptido terapeutico de la presente invencion puede formularse para administracion a un sujeto en necesidad de tratamiento como una formulacion oral, una formulacion parenteral, una formulacion topica, una formulacion acuosa, una formulacion solida, una formulacion liofilizada o una formulación transdermica； se describe tambien un metodo para tratar por lo menos uno de diabetes, y/o hiperglucemia, y/o hipercolesterolemia, y/o hipertension, y/o sindrome metabolico en un sujeto, que comprende: administrar al sujeto un polipeptido de la invencion o formulacion de la invencion.
