Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

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专利权人:

VERTEX PHARMACEUTICALS INCORPORATED

发明人:

FENG YUSHI,LOOKER ADAM,ZHANG YUEGANG,DEMATTEI JOHN,MUDUNURI PRAVEEN,ROEPER STEFANIE,HARRISON CRISTIAN

申请号：

NZ60086508

公开号：

NZ600865A

申请日:

2008.09.15

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

600865 Disclosed is N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1)&bull PEG 400 (polyethylene glycol)&bullKOAc (potassium acetate). Also disclosed are crystalline form and x-ray powder diffraction patterns of Compound 1&bullPEG 400&bullKOAc, pharmaceutical combinations comprising Compound 1&bullPEG 400&bullKOAc, methods of making Compound 1&bullPEG 400&bullKOAc and the use of Compound 1&bullPEG 400&bullKOAc in the manufacture of a medicament. The medicament is useful in the treatment of cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation- fibrinolysis deficiencies, lipid processing deficiencies, lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, COPD, dry-eye disease, and Sjogren&rsquos disease.

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