The present invention relates spiro-cyclic amine derivatives of the formula ( I ) wherein R1 is selected from cyano, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkyl each optionally substituted with CN or one or more fluoro atoms, (3-6C)cycloalkyl, (4-6C)cycloalkenyl or a (8-10C)bicyclic group, each optionally substituted with halogen or (1-4C)alkyl, phenyl, biphenyl, naphthyl, each optionally substituted with one or more substituents independently selected from halogen, cyano, (1-6C)alkyl optionally substituted with one or more fluoro atoms, (1-6C)alkoxy optionally substituted with one or more fluoro atoms, amino, di(1-4C)alkylamino and (3-6C)cycloalkyl optionally substituted with phenyl which may be substituted with (1-4C)alkyl or halogen, phenyl substituted with phenoxy, benzyl, benzyloxy, phenylethyl or monocyclic heterocycle, each optionally substituted with (1-4C)alkyl optionally substituted with one or more fluoro atoms, monocyclic heterocycle optionally independently substituted with halogen, (1-6C)alkyl optionally substituted with one or more fluoro atoms, (3-6C)cycloalkyl, or phenyl optionally substituted with (1-4C)alkyl or halogen, and bicyclic heterocycle optionally substituted with halogen or (1-4C)alkyl optionally substituted with one or more fluoro atoms； -Y-(C n -alkylene)-X- is a linking group wherein Y is attached to R1 and selected from a bond, -O-, -CO-, -S-, -SO-, -SO 2 -, -NH-, -CH=CH-, -C(CF 3 )=CH-, -C‰¡C-, -CH 2 -O-, -O-CO-, -CO-O-, -CO-NH-, -NH-CO-, and trans-cyclopropylene； n is an integer from 0 to 10； and X is attached to the phenylene/pyridyl moiety and selected from a bond, -O-, -S-, -SO-, -SO 2 -, -NH-, -CO-, -CH=CH-, and trans-cyclopropylene； R2 is H or independently selected from one or more substituents selected from halogen, (1-4C)alkoxy and (1-4C)alkyl optionally substituted with one or more fluor atoms； and R3 is (1-4C)alkylene-R4 wherein the alkylene group may be substituted with one or more halogen
