Sean Culbertson;Michael D. Bentley;Samuel P. McManus
发明人:
Michael D. Bentley,Sean Culbertson,Samuel P. McManus
申请号：
US11454971
公开号：
US08252275B2
申请日:
2006.06.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
