This invention with the ideal biology artificial glomerulus offers the biology artificial urine narrow tube which forms the artificial kidney to continuance blood filtration. It is the biology artificial urine narrow tube which consists of with the artificial membrane which covered the inside making use of the urine narrow tube epithelium cell and the container which accommodates this, the said cell konhuruento forms monolayer on the said artificial membrane without stratifying heavily with the application of the MEK inhibiter. The aforementioned urine narrow tube epithelium cell features that contact inhibition function is kept with the application of the MEK inhibiter. As a MEK inhibiter, U0126 is desirable. It is efficient by the fact that the cell which makes the reappearance of kidney function possible is attached, at the same time 24 hours dialysis is possible continually, it is possible in addition to add also the re-absorption performance of the useful substance of the urine narrow tube.本発明は、持続血液濾過に好適なバイオ人工糸球体とともに人工腎臓を構成するバイオ人工尿細管を提供する。尿細管上皮細胞を用いて内面を被覆した人工膜とこれを収容する容器とからなるバイオ人工尿細管であり、該細胞は、MEK阻害剤の適用により重層化することなくコンフルエントな単層を該人工膜上で形成している。前記尿細管上皮細胞は、MEK阻害剤の適用により接触阻害機能を保持していることを特徴とする。MEK阻害剤として、U0126が好ましい。腎臓機能の再現を可能とする細胞を付けることで効率よく、かつ24時間連続的に透析ができ、また尿細管の有用物質の再吸収機能をも付加することができる。
